ContraindicationsHylenex recombinant is contraindicated in patients with known hypersensitivity to hyaluronidase or any of the excipients in Hylenex recombinant. Discontinue Hylenex recombinant if sensitization occurs.
Adverse ReactionsAllergic reactions have been reported in less than 0.1% of patients receiving hyaluronidase. Anaphylactic-like reactions following retrobulbar block or intravenous injections have occurred, rarely.
Drug InteractionsFurosemide, the benzodiazepines, products containing sodium metabisulfite (e.g. in local anesthetic products containing epinephrine) and phenytoin are incompatible with hyaluronidase.
Perform a patch test: Clean the skin and mark out the test area. Subcutaneously inject a tiny amount of Hyaluronidase and wait 10-20 minutes to monitor any adverse responses or allergies, even though they are uncommon. Despite the fact that it is not a strictly mandatory step, a patch test is usually recommended, especially if the treatment is not an emergency. Erythema is normal after injection of hyaluronidase and it will subside right after the treatment.
It is not possible to dissolve fat with hyaluronidase. Therefore, dissolving hyaluronic acid fillers in a fatty region will not affect the fat tissue. As a side note, skin texture will not be affected by hyaluronidase either.
After being dissolved by the hyaluronidase enzyme, a hyaluronic acid dermal filler (or other) can indeed be injected once again. It just depends on when. There needs to be a gap between dissolving and replenishing, depending on the situation this has to be evaluated by a professional assessment.
No, hyaluronidase has no impact whatsoever on Botox nor does it reverse its effects. Only hyaluronic acid based products are dissolvable with hyaluronidase 1500 iu. Because HA is not present in botox, the enzyme hyaluronidase cannot impact it.
You can buy hyaluronidase from many different sources, such as local medical suppliers or online suppliers. You can also buy Hyaluronidase from Marx-Med.com by placing your order directly on our website or by calling us at (646)665-7222.
We do not sell Liporase hyaluronidase due to the lack of transparency in its manufacturing process. The manufacturer of Liporase does not disclose enough data about their manufacturing facility in Asia, nor do they disclose data about the raw materials used, the purification process, their certification, and compliance. Any healthcare professional should be concerned about that, and that's why we will not stock Liporase.Below are some products that can be dissolved by Hyaluronidase 1500 IU injection:The list includes a wider range of products and is not limited to the ones below,
Testicular hyaluronidase is a glycoprotein containing 5% mannose and 2.7% glucosamine. Optimum pH range is 4.5-6.0. The enzyme catalyzes the hydrolysis of endo-N-acetylhexosaminic bonds of hyaluronic acid and chondroitin sulfate A and C (but not B), primarily to tetrasaccharide residues.
Perfect dermal fillers are formulated to give you an instantly rejuvenated appearance. If you, however, are not satisfied with the results of their administration, all you need to do is buy hyaluronidase known as a filler dissolver.
The main function of hyaluronidase in aesthetic medicine is speeding up the natural breakdown of hyaluronic acid dermal filler through hydrolysis. Please note that you can buy hyaluronidase and use it only for hyaluronic acid based dermal fillers.
Filler dissolver hyaluronidase will help eliminate some side effects of dermal fillers, such as, for example, noticeable excess or lump in the treated area. Most people want to remove only part of a dermal filler, so the dose of hyaluronidase is always selected on an individual basis.
Cost of hyaluronidase is significantly lower than the price of dermal fillers. If you see that the volume is excessively increased, buy hyaluronidase and achieve the aesthetic goals that you desire.
Vitrase (hyaluronidase for injection) is the first and only pure, preservative-free, thimerosal-free, ovine hyaluronidase. Vitrase is indicated as an adjuvant to increase the absorption and dispersion of other injected drugs; for hypodermoclysis; and as an adjunct in subcutaneous urography for improving resorption of radiopaque agents.
Vitrase is the only hyaluronidase preparation approved by the U.S. Food and Drug Administration for uses at concentrations >150 USP units/mL. Vitrase is available in 200 USP Units/mL vials in sterile solution. It is only available in a 2 pack.
According to Maytin, hyaluronic acid (hyaluronan, HA) is a simple linear disaccharide polymer creating a huge hydrophilic molecule conferring a large volume of hydration, thereby contributing to the turgor and flexibility of healthy skin. HA also has important biological and physiological functions that have been under-appreciated until recently. New research confirms that HA is dynamically produced by most skin cells, not only fibroblasts but also by keratinocytes. For both fibroblasts and keratinocytes, HA plays a regulatory role in controlling cell physiology through interaction of extracellular HA with a major cell-surface receptor, CD44. This interaction mediates intracellular signaling both directly and indirectly, through CD44 interactions with the cytoskeleton and with EGF and TGFβ receptors. Intact HA tends to exert anti-inflammatory effects via CD44, whereas small and mid-sized fragments (oligosaccharides) are pro-inflammatory via Toll-like receptors. Furthermore, degradation of HA by specific hyaluronidases produces HA fragments that can help to regulate inflammatory processes. (2)
As a medical dermatologist, I have never used hyaluronidase, but recent reports suggest that I might. One of the most debilitating manifestations of scleroderma is microstomia; any treatment that could improve mastication, phonation, and oral hygiene would be valuable. Melvin et al reported improvement of microstomia in a 53-year-old woman by hyaluronidase injections, as documented by a diminution of the MHISS (mouth handicap in systemic sclerosis score). (6) Hoesly et al presented two cases of pretibial myxedema, both of whom responded well to hyaluronidase. The first patient had been recalcitrant to clobetasol and pentoxifylline; the second patient had no prior therapy. (4) Eisert and Nast described two cases of severe keloids that were unresponsive to prior surgery. Both patients had impressive results with a combination of intralesional cryosurgery, triamcinolone, 5-fluorouracil, and hyaluronidase. (7) Kiyohara and Tanimura reported the case of a 47-year-old woman with type 2 diabetes and biopsy-proven scleredema. Monotherapy with hyaluronidase injections demonstrated marked improvement over 18 weeks, as documented by MRI scans. (8)
Perhaps other yet unreported indications exist for hyaluronidase; recalcitrant scleromyxedema and granuloma annulare come to mind. When I finally utilize hyaluronidase, I will smile toward the heavens, thanking my first, cantankerous scleredema patient for encouraging me to go back and study.
Point to Remember: Cosmetic dermatologists performing hyaluronic acid filler procedures must have access to hyaluronidase for emergent and other filler complications. Medical dermatologists may wish to borrow some for recalcitrant disorders such as pretibial myxedema, microstomia of scleroderma, and scleredema.
In this article, Dr. Heymann bridges the gap between medical and cosmetic dermatology which is sorely needed. His delightful article highlights how one aspect of our field helps the other. In this case, his thorough review of hyaluronidase and uses in the medical treatment of scleredema and potentially many others is enlightening. It is a reminder that we can all benefit our patients by removing the stigma of cosmetic versus medical dermatology and learn that by sharing and collaborating we can accomplish more.
Eisert L, Nast A. Treatment of extensive, recalcitrant keloids using a combination of intralesional cryosurgery, triamcinolone, 5-fluorouracil, and hyaluronidase. J Dtsch Dermatol Ges 2019; May 27 [Epub ahead of print].
Hyaluronic acid lyase, also known as Hyaluronidase, is an enzyme that hydrolyzes hyaluronic acid. Hyaluronidase can dissolve unwanted HA filler within 24 hrs. It results in a 90% elimination rate. This 1ml vial with powder requires saline water (included). One vial of this concentrated hyaluronidase powder, once mixed with saline, can make 3mls of filler dissolving solution. It is mainly used to remove or fix HA filler molding but it can also boost the effects of fat-dissolving solutions such as Mesotherapy Lipolysis. Store opened vials in a refrigerator or cold/dry area, never freeze.
The fastest and most effective means of solving the incorrectly, excessively, or unevenly injected hyaluronic acid filler is hyaluronidase - a group of enzymes due to which hyaluronic acid in the body is split into oligomers - low molecular weight fragments.
The South Korean medication Liporase contains a highly active depomilizing enzyme of hyaluronidase 1500 U was elaborated to dissolve hyaluronic acid-based derma filler. In addition, the drug increases the viscosity of hyaluronic acid, which promotes changes in the dermis and connective tissue, and improves the permeability of cell membranes.
Liporase 1,500 I.U of hyaluronidase preparation is presented in the form of a lyophilized powder that contains 1,500 i.u, which is pre-mixed with sterile saline solution. It is important to remember that the product is supplied in pure form without preservatives and should be used immediately after reconstitution. The drug lasts an average of 48 hours.
Adverse reactions after breast liposuction and correction of the \"double\" chin in the form of fibrosis and hyperemia are effectively eliminated with the help of early fan-shaped administration of Liporeise hyaluronidase (500 - 1500 U). The procedure ends with a light massage for even distribution of the product. 59ce067264